A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other ...

A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across ...

Aging can impair stem cell self-renewal and differentiation through molecular damage, inflammation, and changes in the surrounding tissue environment, contributing to slower repair. Experimental ...

Scientists discovered that declining levels of a protein called Menin may help drive aging, and restoring it in older mice reversed several age-related changes in just 30 days. Even more surprisingly, ...

New paper suggests coordinated targeting of G protein-coupled receptors (GPCR) could tackle multiple drivers of aging and age ...

Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks ...

Inflammaging is a state of persistent, low-grade inflammation associated with aging, influenced by immune dysfunction, ...

As we age, our bones become weak and brittle, a process called osteoporosis. This bone loss is caused by changes in the cells ...

Representative immunofluorescence image illustrating the neuroprotective effect of USP4 knockdown in iPSC-derived motor neurons (green) carrying an ALS-linked mutation. Inhibition of USP4 (EPS8 ...

Leveraging single-cell sequencing, this study presents the first cell-resolved molecular map of human scalp aging, revealing that the core mechanism of early senescence involves a significant ...