Nature

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Figure 1: Synthetic strategies to access secondary and tertiary alcohols by carbonyl addition reactions. Despite considerable advances, and the abundance of organometallic reagents developed for ...
Phys.org

Iron catalyst drives asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds

Scientists at the Institute of Science Tokyo (Science Tokyo) have successfully realized the highly selective asymmetric 1,6 addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl ...
Nature

Development of β-amino-carbonyl compounds as androgen receptor antagonists

Androgen receptor (AR) antagonists have proven to be useful in the early control of prostate cancer. The aim of this study was to identify and characterize a novel β-amino-carbonyl-based androgen ...