Tau proteins play an important role in our normal brain function, mainly by helping to stabilize neurons in the brain. But in Alzheimer’s disease, tau proteins can misfold and tangle inside neurons.

Researchers at UCLA Health and UC San Francisco have identified a specific molecular mechanism that explains why certain ...

By Tarun Sai Lomte Researchers report that declining PPP2R5C levels in blood may signal early Alzheimer’s pathology, offering ...

Developed by Veravas Inc., VeraBIND ™ Tau Assay is the first blood-based test that measures pathologically active tau for the early detection of Alzheimer's disease in both asymptomatic and ...

A biomarker test identified tau pathology in Alzheimer's disease before fibrillary tangles developed. Neurofibrillary tangle formation can be prevented by targeting intermediate soluble tau assemblies ...

Two hallmarks of Alzheimer’s—amyloid-β pathology and tau pathology—are linked by a protein complex, the NLRP3 inflammasome. When amyloid-β deposits form, they can activate the NLRP3 inflammasome, ...

For a PET ligand, validation is literally a matter of life and death. Its reliability rides on a direct comparison of tracer uptake in a living person with his or her autopsy result. In the December 3 ...

Some studies of cerebrospinal fluid biomarkers suggest that women accumulate more tau pathology early in Alzheimer’s disease than do men. In the February 4 JAMA Neurology, researchers led by Rachel ...

Alzheimer's disease (AD) is a neurodegenerative disease that affects the central nervous system, and is the cause of approximately 60–80% of dementia cases. Treatments currently approved for AD are ...

Tau proteins play an important role in Alzheimer's disease. Tau helps to stabilize neurons in the brain, but in Alzheimer's disease, tau proteins can misfold and tangle inside neurons. These tangles ...