San Francisco 49ers running back Christian McCaffrey played his second game of the season on Sunday after a prolonged battle with Achilles tendinitis.

Although it might seem like it, the 49ers' season is not over. There are still seven games remaining in the regular season, ...

Earlier this season, San Francisco 49ers tight end George Kittle wore an Iowa State helmet while speaking to reporters after ...

The 49ers sustained several injuries in their 20-17 loss to the Seattle Seahawks on Sunday, but coach Kyle Shanahan is ...

The San Francisco 49ers will conduct three full practices this week in preparation for their Week 11 matchup against the ...

The San Francisco 49ers earned a hard-fought victory on Sunday against the Tampa Bay Buccaneers, securing back-to-back wins for the first time this season and improving their record to 5-4. During the ...

Brock Purdy is dealing with soreness in his right (throwing) shoulder, coach Kyle Shanahan said Monday, and is day ...

The San Francisco 49ers have injury issues at two of the most important positions on their roster entering Week 12. San Francisco 49ers head coach Kyle Shanahan spoke to reporters during a Monday ...

San Francisco 49ers head coach Kyle Shanahan spoke to reporters during a Monday conference call, providing key injury updates the day after the team's ...

Brock Purdy injured his shoulder Sunday during the 49ers' 20-17 loss to the Seattle Seahawks. The 49ers list him as a day to day with shoulder soreness.

The oddsmakers are starting to lose confidence in the 49ers. For the first time since last year, the 49ers are underdogs for ...

Calling Sunday's loss to the Seattle Seahawks disappointing is an understatement, especially for San Francisco 49ers legend ...